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KMID : 0043320100330060863
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Archives of Pharmacal Research
2010 Volume.33 No. 6 p.863 ~ p.866
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Isolation of Virus-cell Fusion Inhibitory Components from the Stem Bark of Styrax japonica S. et Z.
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Woo Eun-Rhan
Lee Dung-Gun
Jin Qing-Long
Jin Hong-Guang
Shin Ji-Eun
Choi Eun-Jin
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Abstract
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Five compounds, styraxjaponoside A (1), matairesinoside (2), egonol glucoside (3), dihydrodehydrodiconiferyl alcohol 9’-O-glucoside (4), and styraxjaponoside B (5) were isolated from the stem bark of Styrax japonica. Among them, compounds 1 and 5 showed significantly high virus-cell fusion inhibitory activity. In addition, compound 5 exhibited almost equivalent virus-cell fusion inhibitory activity to that of dextran sulfate, which is used as a positive control.
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KEYWORD
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Styrax japonica S. et Z., Virus-cell fusion, Anti-HIV, gp120/41, Fusion index, Lignan glycoside
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